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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 1 Reviews
8.5
Supplement Facts
Serving Size: 1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*
Top Medical Research Studies
9
DHA-PS promotes liver recovery
DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.
Highly relevant to liver health
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Read More
9
DHA's Role in Liver Health
Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury.
Study highlights DHA's importance
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on the health of our liver, especially regarding nonalcoholic fatty liver disease (NAFLD). Using a zebrafish model with a specific mutation that prevents the production of DHA, we aimed to understand how this absence affects liver lipid balance and overall liver health.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Read More
8
DHA affects liver function positively
The effect of long-chain n-3 PUFA on liver transcriptome in human obesity.
High relevance to liver health
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects liver function in individuals with obesity. The study involved patients with a body mass index (BMI) of 40 kg/m² or higher. Half of these patients received a supplement of n-3 PUFAs, which included DHA, while the other half received a control treatment of butter.
After eight weeks, liver biopsies were taken and analyzed to see how gene expression was affected. The results showed that DHA treatment significantly influenced various pathways related to metabolism, immunity, and inflammation in the liver. Specifically, we observed that the treatment led to an upregulation of pathways involved in T-cell and B-cell functions, along with lipid metabolism. Interestingly, pathways related to glucagon signaling were downregulated.
Our findings offer valuable insights into DHA’s role in liver health, particularly in how it may help reduce inflammation and improve metabolic functions in obese individuals. This research sets the groundwork for future studies that could further explore the benefits of omega-3 fatty acids for liver disease.
After eight weeks, liver biopsies were taken and analyzed to see how gene expression was affected. The results showed that DHA treatment significantly influenced various pathways related to metabolism, immunity, and inflammation in the liver. Specifically, we observed that the treatment led to an upregulation of pathways involved in T-cell and B-cell functions, along with lipid metabolism. Interestingly, pathways related to glucagon signaling were downregulated.
Our findings offer valuable insights into DHA’s role in liver health, particularly in how it may help reduce inflammation and improve metabolic functions in obese individuals. This research sets the groundwork for future studies that could further explore the benefits of omega-3 fatty acids for liver disease.
Read More
Most Useful Reviews
8
Omega 3 supplement
This omega supplement is recommended by a practising doctor to help replenish omega 3 for those with deficiencies, as well as for pregnant and lactating women and those with liver disease. The herbal composition is excellent!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
9
DHA combined with MCTs beneficial
Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.
Moderately relevant due to combination
We explored the effects of docosahexaenoic acid (DHA) on liver disease, specifically looking at its role in nonalcoholic fatty liver disease (NAFLD) and its potential connection to Alzheimer's disease. Our study conducted on APP/PS1 mice involved four groups of animals fed different diets—one with DHA, one with medium-chain triglycerides (MCTs), and one that combined both treatments.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Read More
9
Docosahexaenoic acid for liver cancer
APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage.
Examines DHA effectiveness in therapy
We explored the effectiveness of docosahexaenoic acid (DHA), particularly when delivered via nanoparticles, in treating liver disease, specifically hepatocellular carcinoma (HCC), in three rodent models. Our focus was on understanding how DHA affects HCC lesions as well as the performance of weighted amide proton transfer (APT) MRI as a monitoring tool.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
Read More
9
Nutrient cocktail improves liver health
Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial.
Mixed nutrient effects observed
We conducted a study to understand how a specific mix of nutrients, including docosahexaenoic acid, impacts liver health in adults suffering from metabolic dysfunction-associated steatotic liver disease (MASLD) due to obesity. This involved a carefully controlled pilot clinical trial where participants were either given a nutrient cocktail or a placebo over three months.
The results were quite promising. Those who received the nutrient cocktail had notable reductions in liver fat content and fibrosis as indicated by improvements in their liver scans. Specifically, we observed an average reduction of 4% in the controlled attenuation parameter (CAP) and 7.8% in transient elastography (TE) scores among the treatment group.
Although docosahexaenoic acid was part of this nutrient blend, the study didn't isolate its effects. Therefore, while the overall findings suggest that such a supplementation might enhance liver health, the individual contribution of docosahexaenoic acid remains unclear. This points towards a need for more targeted research to fully understand its role in treating liver conditions.
The results were quite promising. Those who received the nutrient cocktail had notable reductions in liver fat content and fibrosis as indicated by improvements in their liver scans. Specifically, we observed an average reduction of 4% in the controlled attenuation parameter (CAP) and 7.8% in transient elastography (TE) scores among the treatment group.
Although docosahexaenoic acid was part of this nutrient blend, the study didn't isolate its effects. Therefore, while the overall findings suggest that such a supplementation might enhance liver health, the individual contribution of docosahexaenoic acid remains unclear. This points towards a need for more targeted research to fully understand its role in treating liver conditions.
Read More
9
DHA-PS promotes liver recovery
DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.
Highly relevant to liver health
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Read More
9
Liposomal DHA alters liver fats
Dietary liposomal complexes change the fatty acid composition of hepatic bioactive phospholipids in F1(C57blxDBA2\6) mice, as shown by a lipidomic approach.
Moderate relevance due to study design
We investigated how various dietary liposomal complexes featuring docosahexaenoic acid (DHA) influence liver health. The study used F1 (C57blxDBA2\6) mice over a 3-month period, looking at changes in liver phospholipids due to different diets.
The mice were divided into groups, some receiving a liposomal complex with important ingredients like phosphatidylcholine and fish oil. We found that the mice consuming the PC-CEO-FO-SC liposomal complex saw a significant increase in n-3 fatty acids, particularly DHA, in their liver phospholipids.
This increase in DHA was also linked to a decrease in n-6 fatty acids, such as arachidonic acid. As a result, the ratio between n-6 and n-3 fatty acids improved, which is promising for reducing inflammation and potentially decreasing the risk of chronic diseases related to the liver.
However, while these findings are encouraging, they don't directly isolate DHA's effect specifically on liver disease, so it’s important to interpret the results with caution.
The mice were divided into groups, some receiving a liposomal complex with important ingredients like phosphatidylcholine and fish oil. We found that the mice consuming the PC-CEO-FO-SC liposomal complex saw a significant increase in n-3 fatty acids, particularly DHA, in their liver phospholipids.
This increase in DHA was also linked to a decrease in n-6 fatty acids, such as arachidonic acid. As a result, the ratio between n-6 and n-3 fatty acids improved, which is promising for reducing inflammation and potentially decreasing the risk of chronic diseases related to the liver.
However, while these findings are encouraging, they don't directly isolate DHA's effect specifically on liver disease, so it’s important to interpret the results with caution.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.5
8
Omega 3 supplement
This omega supplement is recommended by a practising doctor to help replenish omega 3 for those with deficiencies, as well as for pregnant and lactating women and those with liver disease. The herbal composition is excellent!
